Chris
Personally I don't like any totally sealed compartment, be it in a hull or superstructure unit. You can guarantee that sooner or later damp or even oil will get into it, even though it is 'sealed' from the outside. Then you have the annoying 'slosh' of liquid inside and no obvious way out. Therefore, there are no totally sealed compartments anywhere on my models, and if of wood, the interior is painted or 'resined'. Having said that, Glynn Guest always leaves his balsa hulls unpainted on their insides, but leaves the hulls 'open' with the superstructures off after a sailing session to dry out if needs be.
Even full-size ships can have problem. Do you remember when HMS illustrious had to be emergency dry-docked because the sealed chamber that allowed filtered seawater into the hull for drawing up into the cooling system was itself leaking into the engine room because the welds had failed. This was a 'sealed' chamber working in reverse.
Buoyancy? Yes polystyrene foam within a hull is a good idea, or even balloons and cut-up swimming floats, if you sail on rough water or there are kamikaze skippers also sailing on your lake! On the other hand, if you build hulls from foam covered resin as does Ron Rees, then the model will float regardless of which way up it is!
Paul.