Most radios that are intended for flight control have some sort of "failsafe" that turns the throttle to minimum in the event of signal loss. OK with a forward only ESC, but the same signal from the receiver that thell a forward only ESC to stop means "go full speed reverse" on an ESC with reverse.
2 fairly essential tools are a Y lead with a spare servo to see what the ESC is seeing, and a servo tester to offer known conditions without the uncertainty introduced by the radio. Both cheap.
In the past, simple radios just took instructions from the stick and passed the information on as a signal to tell the servo to mimic the stick position without messing about with it. Modern electronics has allowed all sorts of cleverness to creep in, which is not always helpful.. Unexpected facilities (like semi active failsafes that are only safe in the right circumstances) can appear as faults, especially if the instructions either pass over the details, or use terms that are misleading to the reader.
As Chas & Dave said, knowing the ESC make & model will help.