Ashley Needham is probably the person to answer that but he has not been on the forum in the last week or so.
Acrylic paints won’t affect Depron but they are vulnerable to abrasion so should be protected. An acrylic varnish should do the job but there may be other options.
you could seal the Depron using an acrylic type resin such as Deluxe Materials EZeKote before painting but it’s not cheap stuff. Sometimes the traditional methods using birch ply are the cheapest and most effective option.
I’m not altogether sure if you could achieve the crispness of a Fire Tender superstructure using Depron but others may be able to advise you.
Colin