Hi Graham,
Not familiar with your particular transmitter, but can not see why you would have problems. Assuming you have two control sticks both with horizontal and vertical movement (4 of your 6 channels). Then just run each motor from each of the 2 vertical channels. Each motor will require its own speed controller. If you are intending to use the BEC feature, ensure you use only one and disable the other (usually requires the power cable to be removed from the plug – be sure to read the instructions that come with the ESC).
If you go to the Gallery – page 11 – and load my album "Le Caux" you will find a wiring diagram which should cover your needs.
Cheers – Ken