If it is a single joint, alignment needs to be, and stay, perfect. That means having the center lines of the motor and prop shaft intersect at the center of the universal's spider. Anywhere else, something will be trying to realign itself, giving a repeating clonk. A resilient mount might reduce that, but will leave the motor constantly trying to realign itself. Anybodys guess how long before you find out what the weakest point of the mounting is.
A better answer would be to use a double universal or a rubber coupler or a dogbone type.