Steve – Not sure what you mean by macro milling. I have small milling machine – table size 400 mm X 145 mm which i use for machining model boat items e.g. apertures in decks (plywood) and superstructure panels (styrene). I made a false/sacrificial table from 18 mm MDF (which is held to the machine table using c/sunk screws into the conventional T nuts. The MDF table is fitted witha protruding batten screwed to the rear edge to act as a back stop. The back stop is set parallel to the machine axis so that any item machined is always parallel/square to the machine axis.
Items are clamped to the MDF using wooden clamps made from scraps of 8 mm ply and wood screws. Items to be machined are marked directly onto the surface with a hard pencil or alternatively onto masking tape affixed to the surface. I find that particularly styrene is prone to producing a fine feathery burr which although it can be removed easily after machining tends to obscure the marking out. To overcome this problem I firstly set the cutter to the marked line and record the setting on the index dials. I then move the table to the next point (counting and recording the number of full turns and record the next reading on the index dial. You do however have to take into account the slackness (or backlash) in the table screws. Using the milling machine produces nice straight and square edges.